One magic mushroom dose eases pain for two weeks

Just one dose of psilocybin, the active ingredient in magic mushrooms, can relieve pain and anxiety for weeks.

It calms brain circuits tied to pain and mood, easing both physical suffering and emotional distress, including depression, say researchers from the University of Pennsylvania School of Medicine.

In studies using mice with chronic nerve injury and inflammatory pain, the researchers found that a single dose of psilocybin reduced both pain and pain-induced anxiety and depression-like behaviours for almost two weeks.

Unlike powerful painkillers such as opioids, psilocybin isn’t addictive.

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