The group, the National Vaccine Information Center (NVIC), says the advertisement is a response to the campaign across the US and elsewhere to restrict parents' freedom of choice over vaccination. California removed the personal belief vaccine exemption in 2015.
Further restrictions are expected as "vaccine proponents whip up irrational fears to justify attacking human rights, including freedom of thought, speech, religious belief and conscience," said NVIC's co-founder Barbara Loe Fisher.
"In a population of 320 million people, a few hundred cases of measles is not a public health emergency to justify the elimination of the legal right to exercise informed consent to vaccination."
The NVIC's electronic advertisement will run with the messages: 'Vaccinations: know the risks and failures' and 'No forced vaccination' on an electronic display that will run three times an hour every day in April.
The NVIC is a non-profit group formed in 1982 "to prevent vaccine injuries and deaths through public education."