One of the arguments used to promote universal use of hormone replacement therapy protection against coronary heart disease has been refuted by a new study from the Netherlands.
In the study, baseline sex hormone concentrations in the urine were measured in 11,284 premenopausal women recruited for a research project on breast cancer. The follow up to the study from 1982 to 1991 identified 45 women who developed coronary heart disease. Their measurements of urinary estrogens and androgens did not differ from those in the whole study population (J Clin Epidemiol, 1997, 50: 275-81).
For more information on HRT see WDDTY vol 6 no 10 and 12, vol 5 nos 4 and 12 and the WDDTY Guide to the Menopause.