Helping you make better health choices

In shops now or delivered to your home from only £3.50 an issue!

Subscribe!

How homocysteine damages your arteries

MagazineDecember 1999 (Vol. 10 Issue 9)How homocysteine damages your arteries

Whether or not your homocysteine levels are elevated depends upon the total methionine content of dietary protein and the amount of vitamin B6, B12 and folic acid in your diet

Whether or not your homocysteine levels are elevated depends upon the total methionine content of dietary protein and the amount of vitamin B6, B12 and folic acid in your diet.

The conversion of homocysteine to methionine is controlled by vitamin B12 and folic acid, which remethylate homocysteine to methionine. The build up of homocysteine causes the formation of homocysteine thiolactone made from methionine in the liver by an enzyme that participates in protein formation and other processes. This build up of homocysteine thiolactone causes low density lipoprotein to become aggregated, or sticky. When LDL homocysteine thiolactone aggregates are released from the blood into the liver, they are taken up by the macrophages of the artery walls to form the foam cells that are seen in early arteriosclerotic plaques.These foam cells then degrade these aggregates and release fat and cholesterol into the developing plaques. The foam cells also release homocysteine thiolactone into surrounding cells of the artery walls, which affect the way that cells handle oxygen. As a result, highly reactive free radicals accumulate within cells, damaging the lining cells of arteries, causing blood clots to be formed and stimulating the growth of arterial muscle cells which form fibrous and degenerative elastic tissue.


How to protect your heart

Magnesium: research misconduct?

You may also be interested in...

Sign up for free today

Sign up now to get your FREE 17-point Plan to Great Health

Free membership gives you access to our latest news reports, use of our community area, forums, blogs, readers' health tips and our twice-weekly
e-news letter.

WDDTY Recommends

Latest Tweet

About

Since 1989, WDDTY has provided thousands of resources on how to beat asthma, arthritis, cancer, depression and many other chronic conditions.

Start by looking in our fully searchable database, active and friendly community forums and the latest health news.

Positive SSL Wildcard

Facebook Twitter

Most Popular Health Website of the Year 2014

© 2010 - 2016 WDDTY Publishing Ltd.
All Rights Reserved