Helping you make better health choices

In shops now or delivered to your home from only £3.50 an issue!

Subscribe!

Losartan

MagazineJuly 1998 (Vol. 9 Issue 4)Losartan

Losartan is one of a new breed of antihypertensives known as angiotensin II antagonists and already, as a new kid on the block, it's causing concern among doctors

Losartan is one of a new breed of antihypertensives known as angiotensin II antagonists and already, as a new kid on the block, it's causing concern among doctors.

Two cases that suggest the drug can cause pancreatitis, or inflammation of the pancreas, have already been reported by doctors.

Interestingly, pancreatitis can be triggered by the earlier generation of antihypertensives known as ACE (angiontension converting enzyme) inhibitors, but it had been thought from early clinical trials on losartan that the angiotensin II antagonists were free of this complication.

Losartan (marketed in the UK as Cozaar, and in the US as Cozaar and Hyzaar), was blamed as the cause of one case of pancreatitis last year, and this has been followed by a case from Leipzig, Germany involving a 42 year old woman (Lancet, 1998; 351: 1178).

Before these concerning reports had come in "from the field", losartan had been viewed as a relatively well tolerated drug, with only 2.3 per cent of patients having to stop treatment during clinical trials. The most common reactions such as diarrhea, dizziness. upper respiratory infection, cough and nasal congestion were almost mirrored in the placebo, or sugar pill, group, suggesting that they were not caused solely by the drug.

Patients who had a known reaction to aspirin and penicillin reacted badly to the drug, and had to have their treatment stopped. Reactions they suffered ranged from swelling of the lips and eyelids, and facial rash. These reactions disappeared soon after stopping treatment.

As with ACE inhibitors, losartan is a dangerous drug to give to pregnant women as it can cause miscarriage and neonatal death. It also needs to be avoided by nursing mothers as losartan may appear in maternal milk.


Home remedy catalogue would be welcome

Mixture linked to miscarriage

You may also be interested in...

Sign up for free today

Sign up now to get your FREE 17-point Plan to Great Health

Free membership gives you access to our latest news reports, use of our community area, forums, blogs, readers' health tips and our twice-weekly
e-news letter.

WDDTY Recommends

Latest Tweet

About

Since 1989, WDDTY has provided thousands of resources on how to beat asthma, arthritis, cancer, depression and many other chronic conditions.

Start by looking in our fully searchable database, active and friendly community forums and the latest health news.

Positive SSL Wildcard

Facebook Twitter

Most Popular Health Website of the Year 2014

© 2010 - 2016 WDDTY Publishing Ltd.
All Rights Reserved