Q:I have heard of a horrendous case of Septrin causing the most severe side effects in a penicillin allergic subject. I understand that this drug is associated with Stevens-Johnson Syndrome. I am not quite sure, but I believe that Septrin has been banned in the States. Could you confirm this, please, and perhaps also collate some data on side effects of this drug? If indeed this is banned in the States, why is it still in use in this country and elsewhere? D. J., Ilford, Essex.
A:According to the 1992 edition Physician's Desk Reference, the US drugs bible (and confirmed by its manufacturer, Wellcome), this drug is still on the market in America.Septrin, known in the states as Septra, is a combination of two synthetic antibiotics (of trimethoprim and sulfamethoxazole), used to treat urinary tract infections, acute middle earache, acute chronic bronchitis in adults, traveller's diarrhoea, pneumocystis carinii pneumonia, one of the side effects of AIDs, as well as prostate and intestinal infections.
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