This woman is searching for information about a pregnancy involving a Rhesus-negative mother and a Rhesus-positive father. Can anyone provide advice on how to deal with this situation? Several women wrote in to say that this should not be a problem in a normal first pregnancy. Three women in your exact situation had the anti-D (also known as Rhogam or Winrho) injection immediately after the birth of their first child to protect future foetuses, and had no problems with their subsequent pregnancies. Another woman emphasised the need for a hands-off third stage, stating that a medicalised birth with a managed third stage may cause complications. She suggests reading Sara Wickham's work on www.withwoman.co.uk and her book "Panacea or Paradox." Other sites to check out include http://thebirthsource.homestead.com/rh.html, the archives of the Radical Midwives on www.radmid.demon.co.uk/rhesus.htm and a good article from a mother's perspective on www.unhinderedliving.com/rhogam.html. Before making the decision as to whether to take the blood product anti-D, check out the package insert which can be found at www.babycenter.com/rhogam/info.pdf and have a look at the NICE guidelines for use, bearing in mind that they are based on advice from the manufacturers rather than midwives: www.nice.org.uk/page.aspx?o=31679.