Click here to read about some of the people we've helped.  We're here to help you, too. Get four essential health reports by joining our e-news community.

Four FREE health reports for you

Register now for our vital and insightful health updates, and get four free health reports to help you live more healthily.

First Name:Email:


Antidepressant overdose can be harmful after all

Fresh evidence suggests that selective serotonin reuptake inhibitors (SSRIs) taken for depressive illness are not safe in overdose, contrary to the belief of some doctors.

Research shows that one of the latest SSRIs, citalopram, causes heart abnormalities and seizure in overdose above 600 mg (15-30 times the usual therapeutic dose). All patients survived with supportive treatment.

In Sweden, where citalopram is the most commonly prescribed antidepressant, serious morbidity and death has resulted from the drug (BMJ, 1998; 316: 307-8).

Steroids have been found to cause depression in patients. Up to 20 per cent of patients on high dose glucocorticoids report disorders, including depression, mania and psychosis, and 75 per cent showed mood variations, says a report from the Psychiatry Department of Addenbrooke's Hospital, Cambridge (BMJ, 1988; 316: 244-5).

WDDTY Blog Speak

Elderly at greater risk with the new antidepressants - The new generation of antidepressants such as the selective serotonin reuptake inhibitors (SSRIs) may be more dangerous than their predecessors for th...

Ssris cause gastrointestinal bleeding - Individuals taking SSRI (selective serotonin reuptake inhibitors) antidepressants may be at increased risk of gastrointestinal bleeding, according to...

The latest antidepressants - The arrival of the SSRIs (selective serotonin reuptake inhibitors), such as Prozac, in the early 1990s was greeted by the medical profession as the fi...

The great depression myth - Every year around the world we take $13bn (£6.6bn)-worth of antidepressants, and more than 80 per cent of those prescriptions are for an SSRI (seroton...

Drugs: - Not for pregnant women, but still. . . - Doctors aren't great at reading drug information sheets, and their patients aren't much better either. That's why pregnant women are prescribed drugs...

SSRIs: Antidepressants are linked to birth abnormalities - Pregnant women who are taking an SSRI antidepressant such as Prozac double the risk of their baby being born with a congenital abnormality, a new stud...

Paroxetine - Paroxetine (marketed in the UK as Seroxat and in the US as Paxil) is an antidepressant that has been blamed for causing chronic hepatitis. The drug, m...

Drugs for depression - An overview of the problems with drugs typically used to treat depression.