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Inhaled steroids lower bone mass in female asthmatics

The use of inhaled steroids for long-term treatment of asthma may lead to reduced bone density in premenopausal women.

As previous studies have shown oral steroids to accelerate bone loss, researchers at Brigham and Women’s Hospital in Boston set out to determine whether inhaled steroids (in this study, triamcinolone acetonide) can also produce this effect.

By monitoring drug use and changes in bone density in 109 premenopausal asthmatic women, they found that the more puffs per day, the greater the change per year in bone density of the whole hip and femur. The bone loss was significant and translated to a more than twofold greater risk of hip fracture than that seen among healthy women aged 65 years or older.

Physicians need to work harder to find the minimum dose required to provide asthma control, and make sure that patients maintain adequate dietary calcium and vitamin D intake, say the researchers. In addition, patients who must stay on high doses should be monitored regularly (N Engl J Med, 2001; 345: 941-7).

Inhaled steroids cause spinal osteoporosis - Inhaled steroids reduce bone density in the spine of women with asthma, according to new research. ...

Bone density level not a key factor in fractures - The decrease in bone density that accompanies aging is only a small factor in the greatly increased risk of hip fracture in older life, researchers ha...

Inhaled steroids slow growth in children - More evidence that inhaled steroids carry the same risks as the oral kind. New research shows that children treated with the inhaled corticosteroid be...

Low bone density or other risk factors? - It is generally assumed that low bone density indicates fracture risk. However, dense bones may not necessarily be sufficient to prevent hip fracture...

Fluoride: hip fracture risk - Fluoride in the water supply actually increases the risk of hip fracture among the elderly, a seven year study among the over 65s of Utah has discover...

Preventing bone loss without drugs - Thinning bones has less to do with the menopause than with Western dietary practices, but it can largely be prevented by diet and regular exercise. .....

Calcium arrests bone loss - A study from the Department of Medicine, University of Auckland, New Zealand, is the latest to demonstrate that taking calcium can slow or prevent ost...

Inhaled steroids stunt children's growth - Any of the inhaled steroids taken by asthmatic children could stunt their growth. ...

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