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There is growing evidence that those proposing to prescribe the drug tamoxifen as a preventative measure to women supposedly at high risk of breast cancer are simply trading one form of the disease for another.
A study by GM Williams and others (The Lancet, 24 April 1993) found liver cancer in 43 per cent of rats after 6 months on the drug. Although the dosage (45.2mg per kg of body weight per day) was many times higher than would be given to women (0.8mg/kg per day), the study found that lower doses were carcinogenic over longer periods. Earlier studies have shown that doses equivalent to those given to women produce tumours in 11.5 per cent of rats.
Minimising breast cancer risk - Maintain a healthy weight. Obesity increases your risk of postmenopausal breast cancer by 50 to 100 per cent (Am J Clin Nutrition, 1987; 45: 289). It...
Studies exaggerate genetic basis of breast cancer risk - Studies estimating the lifetime risk of women with the BRCA1 and BRCA2 genetic mutation developing breast cancer may have exaggerated the risk by only...
Cancer drug tamoxifen takes another knock - The reputation of the breast cancer drug tamoxifen has taken another serious knock following the publication of two European trials that show it is no...
Contraceptive has high cancer risk - Depo-Provera, the long-lasting contraceptive that can be injected, doubles the risk of breast cancer among women who have taken it for less than five...
Breast cancer-the unkindest cut - Most breast cancer surgeons engage in surgical overkill, and many safety questions surround the new wonder drugs. ... ...
Cancer risk from high wires - People who live close to high voltage cables are at increased risk of developing cancer, according to two Swedish and one Danish studies. ...
Bone mass points to breast cancer risk - Bone mass levels may be another indicator to determine a woman's risk of developing breast cancer, researchers have discovered. ...
Taking tamoxifen for breast cancer - what are the risks? - Q:Can you tell me about the risks of tamoxifen for women at risk of developing breast cancer? C. H., London. ... ...
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