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Ultrasound:a poor predictor of down's syndrome

Using second trimester ultrasound to detect Down's syndrome fetuses results in more fetal losses due to amniocentesis than cases of Down's detected, according to a new meta analysis.

The analysis, which looked at 56 studies involving 1930 fetuses with Down's syndrome and 130,365 unaffected fetuses, found that examining the nuchal fold at the back of the fetus' neck was a poor way to detect affected babies. Using this method resulted in a high rate of false positive diagnoses. Further more, say the researchers, between 4454 and 87,413 women at average risk of an affected fetus would need to be scanned to detect one case of Down's.

The researchers also note that using ultrasound to select women for amniocentesis increases the number of healthy babies lost as a complication of the procedure. Also recognised is the enormous stress caused by a false positive ultrasound. Even when a subsequent scan shows the baby to be healthy, many mothers continue to believe that there must be something wrong with their babies (J Am Med Assoc, 2001; 285: 1044-55).

WDDTY Blog Speak

Amniocentesis - Any thoughts on this pregnancy test (which we erroneously described as a 'condition', apologies for which), asked a reader last time.

Amniocentesis was not such a bad deal - Recently, my daughter had a slightly problematic reading in her blood and was advised to have an amniocentesis. I was very worried because of what I h...

Letting mothers lead - What do mothers want from midwives? Over the years, I have been privileged to listen to many mothers. No matter what their age or experience most wan...

Low-iron mums: bigger babies - Perhaps Mother Nature got it right after all. It seems pregnant women are supposed to become anemic in order to give birth to large, healthy babies. ....

Torn up by the big return - During the second trimester of my second pregnancy, seven of us formed an independent pregnancy group, with no agenda but ourselves, our pregnant feel...

Vitamins help healthy babies - Yet more evidence has emerged of the importance of women's nutrition in their having healthy babies. ...

Ultrasound scans: small babies - Frequent prenatal ultrasound exposure could restrict fetal growth by a third. ...

The scandal of the benzo babies - We hear so much about medical blunders that it seems unbelievable that a scandal involving more than one million children in the UK alone has been goi...

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